Ortigas Center is the second most important commercial and business district (after Makati) in Metro Manila, Philippines. With an area of at least 100 hectares, the district is located at the boundary of Pasig City, Mandaluyong City, and Quezon City. It is governed by Ortigas Center Association, Inc.

It is home to many shopping malls, skyscrapers, and nightlife bars and restaurants. Ortigas Center is home to the St. Francis Square, Asian Development Bank, a Shangri-La hotel and is also the headquarters of San Miguel Corporation, Jollibee Foods Corporation, and the Philippine branch of HSBC. It also homes the Banco de Oro main office owned by mall taipan Henry Sy, Sr. Ortigas Center is also the location SM Megamall, which was the largest mall in the country prior to the completion of the SM Mall of Asia.

Ortigas Center is surrounded by the streets of EDSA to the west, Ortigas Avenue to the north, Meralco Avenue to the east, and Shaw Boulevard to the south.